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Introduction: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder, autoimmune in nature that predominatelyaffects synovial joints. Being a crippling disease is a leading cause of disability that often reduces the quality of life and impairspatients ability to work.Aims and Objectives: The aim of the study was to compare the effect of different treatment regimens on patients with activeRA treated at a tertiary care hospital.Materials and Methods: This was a prospective, open labeled, parallel arm, randomized, and single-center study performed ina tertiary care teaching hospital (Chennai Medical College Hospital and Research Centre [SRM Groups], Irungalur, Tiruchirapalli)and was conducted at outpatient clinics. Total duration of the study period was 24 weeks. All the patients were having activeRA and were on oral methotrexate (first-line disease-modifying antirheumatic drug) at the time of recruitment.Statistical Analysis: All the data were initially entered into Microsoft Excel 2010 and later these spreadsheets were used foranalysis. Statistical analysis was done using SPSS version 20.0.Conclusion: Combination therapy of pitavastatin and methotrexate is better than methotrexate monotherapy and combinationtherapy of rosuvastatin and methotrexate.
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Objective: The objective of the study was to find out the prevalence of Vitamin D deficiency among patients with type II diabetesmellitus (DM) and to assess the effect of Vitamin D in the control of blood sugar and lipid profile among patients with type 2 DM.Material and Methods: Study setting: This study was conducted at diabetic clinic, Chennai Medical College Hospital andResearch Centre, Irungalur, Tiruchirappalli. Study design: The present study was a hospital-based analytical cross-sectionaldesign. Sample size: The sample size was taken as 90 (using the formula 4pq/l2). Analysis: The data collected were entered andanalyzed using the SPSS software package (Version 21). Descriptive statistics (mean, standard deviation and 95% confidenceinterval) and appropriate tests of significance (ANOVA) were applied to establish the relationship between the study variables.P < 0.05 was considered to be statistically significant.Results: We found that there was a significant reduction in all the glycemic indicators over the progressive weeks among thegroup of participants receiving Vitamin D supplements. We have also reported a uniform reduction in all the lipid profile valuesand glycemic indicators across all the three groups in the progressive weeks, with a significant reduction in the group receivingVitamin D supplements.Conclusions: Vitamin D supplementation improves glycemic control and can reduce or prevent the development of insulinresistance in type 2 diabetes mellitus patients. Considering the multitude of diseases associated with Vitamin D deficiency,increasing the population’s awareness of the beneficial effect of Vitamin D on health will be an important strategy overall.
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Acute kidney injury is a threatening complication of pregnancy causing serious maternal and fetal morbidity and mortality,common in developing countries.METHODS:A observational study was done between January 2018 to November 2018 to report the incidence,clinical spectrum and maternal&fetal outcome in AKI.RESULTS:Total number of patients 40,Mean age–25.3± 4.3 yrs.The incidence of AKI in pregnancy was 6%.Incidence of AKI most common in Postpartum period(80%),causes of AKI was Sepsis(40%),HELLP(20%),Postpartum hemorrhage (20%),Auptio placenta (15%),Acute fatty liver of pregnancy (5%).Among them 80% of patients having preeclampsia as common risk factor.Live births was 80%.Among total pregnancy related AKIs 14 patients were managed conservatively and 26 needed dialysis. recovered patients were (N=38) 95%,and mortality was (N=2)5%.CONCLUSION:AKI in pregnancy commonly occurred in Postpartum period and Sepsis is the most common etiology
ABSTRACT
Paraquat poisoning is one of the causes of AKI, the mechanism of toxicity being the production of reactive oxygen species,thereby causing toxicity at the cellular level. The aim of this study is to determine the requirement of haemodialysis and the severity of toxicity, depending upon the amount ingested.It is found that in Paraquat poisoning, the intervention with pre–emptive haemodialysisis not useful in decreasing the mortality. Ingestion under the influence of alcohol has higher mortality.Amount of poison ingested has a great impact and is directly proportional to the mortality. Oral ulcers, hepatic involvement, ARDS and MODS all reflected grave prognosis ultimately leading to death. The overall mortality in the study is 51%.